Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. Get the information you need about this product on our site designed especially for pet owners. Search. It rapidly kills 100% adult fleas within a short period of 12 hours. A kitten in the 1.7X group developed mydriasis. Before using or dispensing any product, read and carefully observe the label directions. In some cases death has been reported. Because the weights of the ferrets in this study ranged from 2.0 to 4.0 lb (0.9 kg to 1.8 kg), ferrets received a range of doses from 51.0 to 106.9 mg/lb (112 to 235 mg/kg) of imidacloprid and 5 to 10.5 mg/lb (11 to 23 mg/kg) of moxidectin. Advantage® II uses imidacloprid to attack the flea’s nervous system and pyriproxyfen to prevent development of fleas. Use only the 0.4 mL Advantage Multi for Cats in ferrets. Harmful if swallowed. Advantage Multi® for Cats(10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. One owner reported a headache caused by chemical odor of the product. Bayer HealthCare LLC, Animal Health Division, P.O. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Cats should be given within one month of the last dose of the former medication. PRICE (CAD) * $12.59: Type Purple - Advantage Multi 18 - Cats Over 9 lbs, each dose: QTY. Baytril® Otic is a topical emulsion for the treatment of canine otitis externa through the use of enrofloxacin and silver sulfadiazine. Foreign Market Experience: Because the following events were reported voluntarily during post-approval use of the product in foreign markets, it is not always possible to reliably establish a causal relationship to drug exposure. Adverse reactions in ferrets following treatment included: pruritus/scratching, scabbing, redness, wounds and inflammation at the treatment site; lethargy; and chemical odor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. People with known hypersensitivity to benzyl alcohol, imidacloprid, or moxidectin should administer the product with caution. CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations on ferrets. Causal relationship to the drug could not be determined. All 12 kittens were either anorexic or had decreased appetite for at least 1 day following treatment. Advantage Multi for Cats controls heartworms, fleas and gastrointestinal worms like hookworms and roundworms. Learn more about this monthly formula. This proportion difference is noteworthy because when Advantage multi for dogs with a higher percentage of moxidectin is given to felines, it can cause severe poisoning in them. Post-Approval Experience: The following adverse events are based on postapproval adverse drug experience reporting. Advantage Multi ® 18 for Cats For cats weighing 9.1-18 lbs. One owner reported a tingling sensation of the lips after kissing the treatment site. At the discretion of the veterinarian, cats older than 6 months of age may be tested to determine the presence of existing heartworm infection before treatment with Advantage Multi for Cats (See ADVERSE REACTIONS - Foreign Market Experience). Mild, transient hypersalivation occurred in two of the cats. The effectiveness of Advantage Multi for Cats in ferrets weighing over 4.4 lbs. Waterproof Flea and Tick Control for 3 Months. To report suspected adverse events and/or obtain a copy of the SDS or for technical assistance, call Bayer Animal Heath at 1-890-422-9874. Checkout . Oral Study in Cats: The oral safety of Advantage Multi for Cats was tested in case of accidental oral ingestion. The chemical name of moxidectin is [6R, 23E, 25S(E)]-5-O- Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino) milbemycin B. Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328 and 6,001,858. The active ingredient, imidacloprid, spreads over your cat's body to kill fleas through contact so they do not have to bite your cat to die. It rapidly kills 100% adult fleas within a short period of 12 hours. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. Advantage Multi Cats Treatment of ferrets weighing less than 2.0 lbs (0.9 kg) should be based on a risk-benefit assessment. 01582 842096 01582 842096. Have person sip a glass of water if able to swallow. Cats treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the cat. Twist the cap to break the seal and then remove cap from the tube. In households with multiple pets, keep animals separated to prevent licking of the application site. This is temporary and does not affect the safety and effectiveness of the product. During another field study, a 16-year-old cat with renal disease slept in the same place without moving for two days following application. Login . Do not get this product in the cat’s mouth or eyes or allow the cat to lick the application site for 30 minutes. Advantage® II uses imidacloprid to attack the flea’s nervous system and pyriproxyfen to prevent development of fleas. Not all adverse reactions are reported to FDA CVM. Studies in Kittens: Advantage Multi for Cats was topically applied at 0, 1, 3, and 5X the maximum dose to 48 healthy 9-week-old kittens on days 0, 28, and 56. Advantage® II for Cats. Owners also reported stiffening of the hair at the treatment site, however, this is expected with application of a topical product and is not considered an adverse reaction. This multipurpose treatment effectively prevents heartworms, treats gastrointestinal worms, fleas, and ear mites in cats. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Ferrets were 78 to 101 days old (11.1 to 14.4 weeks) and weighed between 1.1 to 1.8 lb (0.5 to 0.8 kg) body weight on the day of dosing, resulting in doses ranges 22.0-36.8 mg/lb (48.3-81.0 mg/kg) imidacloprid and 2.2-3.7 mg/lb (4.8-8.0 mg/kg) moxidectin. Dose Tolerance Study: Eight healthy juvenile cats were topically dosed with a single application of Advantage Multi for Cats at 10 times the recommended dose volume. All abnormalities resolved without treatment or supportive care. Necropsy could not determine the cause of death. Advantage Multi for Cats is a medication with two active ingredients - Imidacloprid and Moxidectin. Advantage Multi for Cats provides broad-spectrum parasite protection in a convenient monthly application. How does Advantage Multi for Cats work? If contact with eyes occurs, hold eyelids open and flush with copious amounts of water for 15 minutes. No adverse reactions were associated with the topical application of Advantage Multi for Cats to experimentally heartworm-infected cats. Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. Store at temperatures between 4°C (39°F) and 25°C (77°F), avoiding excess heat or cold. Advantage is a spot-on solution that is easy to apply and kills fleas on contact, so fleas don’t have to bite to die. Profender Spon On for Cats 1 - 5 lbs - GREEN - 2 tubes - $19.70 | Wormers | Advantage Multi for Dogs & Cats Online $28.95 3pk If swallowed, call poison control center or physician immediately for treatment advice. Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. Advantage Multi for Cats must be given once a month. Remove one dose applicator tube from the package. Advantage Multi for Cats may be administered year-around or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. Advantage Multi for Cats is a monthly, topical solution that ensures your cat is in a happy and comfortable condition! Pulmonary inflammation (1-5X) and lymphoid hyperplasia (2-1X, 4-3X) were seen in treated kittens. 5. The following abnormal clinical signs were reported during the study: wet, matted, and/or greasy appearance to the hair, shaking of the head and/or body, rubbing of dose site on cage, and shedding. Discount Drontal / Drontal Plus Allwormer Chewable Tablets for Dogs and Cats Online from $26.95 & Discount Pet Meds. Causes eye irritation. 5. Product Label. The recommended minimum dose for a ferret is 9 mg/lb (20.0 mg/kg) imidacloprid and 0.9 mg/lb (2 mg/kg) moxidectin, once a month, by topical administration. An easy-to-give soft chew for active and aging dogs to help them maintain ongoing whole body comfort for multiple body systems. Advantage is a once a month topical flea treatment for cats and kittens over 8 weeks or older and dogs and puppies 7 weeks or older. Baytril® (enrofloxacin) Antibacterial Tablets is a broad-spectrum fluoroquinolone for management of bacterial pathogens, with activity against Gram-negative and Gram-positive bacteria. 1. Advantage Multi for Cats may be administered year-around or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. At 243-245 days post-infection, immunoserology and echocardiography were performed to identify cats with adult heartworm burdens similar to naturally-acquired infections. The 0.23 mL size does not provide an effective dose and the 0.8 mL size could result in an overdose. Learn more about this monthly formula. Advantage II Flea Prevention for Small Cats, 6-Dose Small Cat Flea Prevention, 5-9 Pounds Advantage Multi For Cats Heartworm disease is often overlooked in cats but your furry friend will be protected by Advantage Multi for cats. body weight. A third cat became ill on day 3 and died with signs and lesions attributable to panleukopenia on day 7 after moxidectin application. Advantage Multi for Cats is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. One kitten from the 3X group had a slow pupillary light response two days after treatment and one had tremors the day after treatment. Advantage Multi (Advocate) for Cats is a monthly spot-on treatment that treats broad spectrum parasitic infestations. Advantage Multi for Cats is a broad-spectrum parasiticide that works to not only kill fleas on cats, but also eliminate ticks and ear mites. Wash skin immediately with plenty of soap and water. ... TevraPet FirstAct Plus Flea and Tick Topical for Cats over 1.5lbs, 3 Dose Flea and Tick Prevention. Flat shipping $3.99/order worldwide. Product Label. In humans, ocular and dermal irritation, nausea, numbness or tingling of the mouth and lips, anaphylaxis, pruritus, vomiting, and tongue/taste abnormalities have been reported following exposure to this product. Do not induce vomiting unless told to do so by the poison control center or physician. This product kills 98-100% of the fleas on cats and dogs within 12 hours. There was a post-treatment loss of body weight in treated kittens compared to control kittens. Advantage for kittens is available in packs of four, and Advantage for small and large cats is available in packs of four or six. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Lift tube away from skin before releasing pressure on tube. 4. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug. It works at various parasite life stages and can be used as an alternative to Revolution.. The following adverse events in cats are listed in decreasing order of reporting frequency: hypersalivation, depression/lethargy, application site reactions (alopecia, pruritus, lesions, and erythema), decreased appetite, vomiting, hyperactivity, ataxia, trembling, and behavior disorder (hiding). Adverse events reported in ferrets topically treated with 0.4 mL imidacloprid + moxidectin for cats included: malaise, vomiting, diarrhea, shaking, mydriasis, hypersalivation with abnormal neurologic signs, seizures, death, generalized hematoma of the body, and alopecia at the treatment site. Advantage Multi for Cats kills adult fleas (Ctenocephalides felis) and is indicated for the treatment of flea infestations. Two kittens in the 5.2X group developed mydriasis, salivation, depression, squinting, and poor appetite. PRICE (CAD) * $13.33 * Applicable prescription fee, shipping & taxes will be calculated at checkout However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. A waterproof solution, Advocate controls parasitic re-infestations by remaining active for a month. Prevent heartworm disease and control ear mites in cats. Type Orange - Advantage Multi 9 - Cats 9 lbs & Under, each dose: QTY. Cats may experience hypersalivation, tremors, vomiting and decreased appetite if Advantage Multi for Cats is inadvertently administered orally or through grooming/licking of the application site. 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